Table of contents


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Editorials

Reproducing data p541

doi:10.1038/ncb0606-541a


Nothing to hide p541

doi:10.1038/ncb0606-541b


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Obituary

Cecile M. Pickart 1954–2006 pp542 - 543

Mark Hochstrasser & Robert Cohen

doi:10.1038/ncb0606-542


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Book Review

Will cells as cinema sell? p544

Thoru Pederson reviews Exploring the Living Cell by Véronique Kleiner & Christian Sardet

doi:10.1038/ncb0606-544


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News and Views

Semaphorin pathways orchestrate osteogenesis pp545 - 547

Luca Tamagnone & Silvia Giordano

doi:10.1038/ncb0606-545

Semaphorins regulate a variety of biological processes, including axon guidance, neuronal migration, angiogenesis, cardiogenesis and immune responses. Semaphorin 6D is now shown to regulate osteoclast function during bone development, through its association with its receptor plexinA1. This activity implicates a signalling pathway known to transcriptionally regulate cell differentiation and involves the receptor Trem2 and the adaptor DAP12.


Survival choices pp547 - 549

Thomas A. Kunkel & Bennett Van Houten

doi:10.1038/ncb0606-547

The recent discovery of many new mammalian DNA polymerases has left researchers trying to assign their biological functions. Surprising evidence has just emerged indicating that DNA polymerase kappa, an enzyme implicated in the bypass of replication blocks, has a role in gap-filling synthesis during nucleotide excision repair (NER) of DNA adducts.


Lamin in the spindle matrix p550

Sinéad Hayes

doi:10.1038/ncb0606-550


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Articles

p63 regulates an adhesion programme and cell survival in epithelial cells pp551 - 561

Danielle K. Carroll, Jason S. Carroll, Chee-Onn Leong, Fang Cheng, Myles Brown, Alea. A. Mills, Joan S. Brugge & Leif W. Ellisen

doi:10.1038/ncb1420


Processive bidirectional motion of dynein–dynactin complexes in vitro pp562 - 570

Jennifer L. Ross, Karen Wallace, Henry Shuman, Yale E. Goldman & Erika L.F. Holzbaur

doi:10.1038/ncb1421


A global analysis of cross-talk in a mammalian cellular signalling network pp571 - 580

Madhusudan Natarajan, Keng-Mean Lin, Robert C. Hsueh, Paul C. Sternweis & Rama Ranganathan

doi:10.1038/ncb1418


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Letters

Molecular architecture of a kinetochore–microtubule attachment site pp581 - 585

Ajit P. Joglekar, David C. Bouck, Jeffrey N. Molk, Kerry S. Bloom & Edward D. Salmon

doi:10.1038/ncb1414


Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization pp586 - 593

Yasushi Izumi, Nao Ohta, Kanako Hisata, Thomas Raabe & Fumio Matsuzaki

doi:10.1038/ncb1409


The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts pp594 - 600

Karsten H. Siller, Clemens Cabernard & Chris Q. Doe

doi:10.1038/ncb1412



Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C pp607 - 614

Michelle J. Hayes, Yuu Kimata, Samantha L. Wattam, Catherine Lindon, Guojie Mao, Hiroyuki Yamano & Andrew M. Fry

doi:10.1038/ncb1410


Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis pp615 - 622

Noriko Takegahara, Hyota Takamatsu, Toshihiko Toyofuku, Tohru Tsujimura, Tatsusada Okuno, Kazunori Yukawa, Masayuki Mizui, Midori Yamamoto, Durbaka V.R. Prasad, Kazuhiro Suzuki, Masaru Ishii, Kenta Terai, Masayuki Moriya, Yuji Nakatsuji, Saburo Sakoda, Shintaro Sato, Shizuo Akira, Kiyoshi Takeda, Masanori Inui, Toshiyuki Takai, Masahito Ikawa, Masaru Okabe, Atsushi Kumanogoh & Hitoshi Kikutani

doi:10.1038/ncb1416

See also: News and Views by Tamagnone & Giordano


Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells pp623 - 630

Katia Ancelin, Ulrike C. Lange, Petra Hajkova, Robert Schneider, Andrew J. Bannister, Tony Kouzarides & M. Azim Surani

doi:10.1038/ncb1413


Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis pp631 - 639

Jung Hwa Kim, Hee June Choi, Bogyou Kim, Mi Hyang Kim, Ji Min Lee, Ik Soo Kim, Moon Hee Lee, Soo Joon Choi, Keun Il Kim, Su-Il Kim, Chin Ha Chung & Sung Hee Baek

doi:10.1038/ncb1415


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Errata

Erratum p642

doi:10.1038/ncb1422


Erratum p642

doi:10.1038/ncb1423


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