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Letter

Nature Cell Biology 8, 581–585 (1 June 2006) | doi:10.1038/ncb1414

Molecular architecture of a kinetochore|[ndash]|microtubule attachment site

Ajit P. Joglekar , David C. Bouck , Jeffrey N. Molk , Kerry S. Bloom & Edward D. Salmon

Kinetochore attachment to spindle microtubule plus-ends is necessary for accurate chromosome segregation during cell division in all eukaryotes. The centromeric DNA of each chromosome is linked to microtubule plus-ends by eight structural-protein complexes.