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Letter
Nature Cell Biology 8, 594–600 (1 June 2006) | doi:10.1038/ncb1412
The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts
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Abstract
Asymmetric cell division generates cell diversity during development and regulates stem-cell self-renewal in Drosophila and mammals. In Drosophila, neuroblasts align their spindle with a cortical Partner of Inscuteable (Pins)–Gαi crescent to divide asymmetrically, but the link between cortical polarity and the mitotic spindle is poorly understood.
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