Nature Cell Biology 8, 545 - 547 (2006)
doi:10.1038/ncb0606-545
Semaphorin pathways orchestrate osteogenesisLuca Tamagnone
& Silvia Giordano
Luca Tamagnone and Silvia Giordano are in the Division of Molecular Oncology, IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy. silvia.giordano@ircc.it
Semaphorins regulate a variety of biological processes, including axon guidance, neuronal migration, angiogenesis, cardiogenesis and immune responses. Semaphorin 6D is now shown to regulate osteoclast function during bone development, through its association with its receptor plexinA1. This activity implicates a signalling pathway known to transcriptionally regulate cell differentiation and involves the receptor Trem2 and the adaptor DAP12.
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