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Nature Cell Biology 8, 427–429 (1 May 2006) | doi:10.1038/ncb0506-427
The ABCs of centromeres
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Abstract
Kinetochores — a specialized structure that forms at centromeres — serve as the contact point between spindle microtubules and the chromosomes, ensuring normal segregation to daughter cells during mitosis and meiosis. In principle, this function could be accomplished by a single protein that binds both centromeric chromatin and microtubules, coupled with regulation of microtubule assembly and disassembly.
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