Table of contents
May 2006, Volume 8 No 5 pp425-540
About the coverEditorial
Sharing science - p425
doi:10.1038/ncb0506-425
Full Text - Sharing science | PDF (106 KB) - Sharing science
News and Views
The ABCs of centromeres - pp427 - 429
Barbara Mellone, Sylvia Erhardt & Gary H. Karpen
doi:10.1038/ncb0506-427
Accurate segregation of genetic information during cell division relies on a multiprotein complex called the kinetochore, whose formation requires specialized centromeric chromatin. Two papers in this issue of Nature Cell Biology identify a multitude of new vertebrate kinetochore proteins that provide insight into the link between centromeric chromatin and the kinetochore, and suggest a functional relationship between centromeres and nucleoli during interphase.
Full Text - The ABCs of centromeres | PDF (217 KB) - The ABCs of centromeres
Protein expression: one by one - p429
Myrto Raftopoulou
doi:10.1038/ncb0506-429
Full Text - Protein expression: one by one | PDF (123 KB) - Protein expression: one by one
Pore-ing the right dose - pp430 - 431
Christopher R. Brown & Pamela A. Silver
doi:10.1038/ncb0506-430
Dosage compensation in Drosophila melanogaster is distinguished by the hypertranscription of the male X chromosome. New findings show that this process requires the nuclear pore complex.
Full Text - Pore-ing the right dose | PDF (159 KB) - Pore-ing the right dose
Filling the GAP for dynamin - pp432 - 433
Jenny E. Hinshaw
doi:10.1038/ncb0506-432
Endocytosis in eukaryotic cells involves numerous specialized protein complexes and lipid domains. One particularly intriguing protein is dynamin, a large GTPase that is very different from other GTPases. Now, phospholipase D has been identified as surprising regulator of dynamin's GTPase activity.
Full Text - Filling the GAP for dynamin | PDF (286 KB) - Filling the GAP for dynamin
Separating sisters - p434
Sinéad Hayes
doi:10.1038/ncb0506-434
Full Text - Separating sisters | PDF (117 KB) - Separating sisters
Articles
Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5 - pp435 - 445
Hassan Mziaut, Mirko Trajkovski, Stephan Kersting, Armin Ehninger, Anke Altkrüger, Régis P. Lemaitre, Darja Schmidt, Hans-Detlev Saeger, Myung-Shik Lee, David N. Drechsel, Stefan Müller & Michele Solimena
doi:10.1038/ncb1395
Abstract - | Full Text - Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5 | PDF (1,031 KB) - Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5 | Supplementary information
The CENP-H–I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres - pp446 - 457
Masahiro Okada, Iain M. Cheeseman, Tetsuya Hori, Katsuya Okawa, Ian X. McLeod, John R. Yates, III, Arshad Desai & Tatsuo Fukagawa
doi:10.1038/ncb1396
Abstract - | Full Text - The CENP-H–I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres | PDF (5,728 KB) - The CENP-H–I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres | Supplementary information
See also: News and Views by Mellone et al.
The human CENP-A centromeric nucleosome-associated complex - pp458 - 469
Daniel R. Foltz, Lars E. T. Jansen, Ben E. Black, Aaron O. Bailey, John R. Yates, III & Don W. Cleveland
doi:10.1038/ncb1397
Abstract - | Full Text - The human CENP-A centromeric nucleosome-associated complex | PDF (2,654 KB) - The human CENP-A centromeric nucleosome-associated complex | Supplementary information
See also: News and Views by Mellone et al.
Letters
Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro - pp470 - 476
Megan T. Valentine, Polly M. Fordyce, Troy C. Krzysiak, Susan P. Gilbert & Steven M. Block
doi:10.1038/ncb1394
First Paragraph - | Full Text - Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro | PDF (764 KB) - Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro | Supplementary information
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis - pp477 - 484
Chang S. Lee, Il S. Kim, Jong B. Park, Mi N. Lee, Hye Y. Lee, Pann-Ghill Suh & Sung H. Ryu
doi:10.1038/ncb1401
First Paragraph - | Full Text - The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis | PDF (1,967 KB) - The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis | Supplementary information
See also: News and Views by Hinshaw
Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling - pp485 - 491
Katsuhiko Asanuma, Etsuko Yanagida-Asanuma, Christian Faul, Yasuhiko Tomino, Kwanghee Kim & Peter Mundel
doi:10.1038/ncb1400
First Paragraph - | Full Text - Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling | PDF (905 KB) - Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling | Supplementary information
Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos - pp492 - 500
Rosana Muñoz, Mauricio Moreno, Carlos Oliva, Claudio Orbenes & Juan Larraín
doi:10.1038/ncb1399
First Paragraph - | Full Text - Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos | PDF (1,663 KB) - Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos | Supplementary information
The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt–
-catenin signalling through Dishevelled - pp501 - 508
Yosuke Funato, Tatsuo Michiue, Makoto Asashima & Hiroaki Miki
doi:10.1038/ncb1405
First Paragraph - | Full Text - The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt–
-catenin signalling through Dishevelled | PDF (1,412 KB) - The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt–
-catenin signalling through Dishevelled | Supplementary information
A ubiquitin-interacting motif protects polyubiquitinated Met4 from degradation by the 26S proteasome - pp509 - 515
Karin Flick, Shahri Raasi, Hongwei Zhang, James L. Yen & Peter Kaiser
doi:10.1038/ncb1402
First Paragraph - | Full Text - A ubiquitin-interacting motif protects polyubiquitinated Met4 from degradation by the 26S proteasome | PDF (3,419 KB) - A ubiquitin-interacting motif protects polyubiquitinated Met4 from degradation by the 26S proteasome | Supplementary information
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function - pp516 - 523
Xuming Mao, Chintan K. Kikani, Ramon A. Riojas, Paul Langlais, Lixin Wang, Fresnida J. Ramos, Qichen Fang, Christine Y. Christ-Roberts, Jenny Y. Hong, Ryang-Yeo Kim, Feng Liu & Lily Q. Dong
doi:10.1038/ncb1404
First Paragraph - | Full Text - APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function | PDF (7,027 KB) - APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function | Supplementary information
Loss of the VHR dual-specific phosphatase causescell-cycle arrest and senescence - pp524 - 531
Souad Rahmouni, Fabio Cerignoli, Andres Alonso, Toshiya Tsutji, Rachel Henkens, Changjun Zhu, Christine Louis-dit-Sully, Michel Moutschen, Wei Jiang & Tomas Mustelin
doi:10.1038/ncb1398
First Paragraph - | Full Text - Loss of the VHR dual-specific phosphatase causescell-cycle arrest and senescence | PDF (8,672 KB) - Loss of the VHR dual-specific phosphatase causescell-cycle arrest and senescence | Supplementary information
Chromatin signatures of pluripotent cell lines - pp532 - 538
Véronique Azuara, Pascale Perry, Stephan Sauer, Mikhail Spivakov, Helle F. Jørgensen, Rosalind M. John, Mina Gouti, Miguel Casanova, Gary Warnes, Matthias Merkenschlager & Amanda G. Fisher
doi:10.1038/ncb1403
First Paragraph - | Full Text - Chromatin signatures of pluripotent cell lines | PDF (969 KB) - Chromatin signatures of pluripotent cell lines | Supplementary information
Brief Communication
APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division - pp539 - 540
Alexandra Reis, Heng-Yu Chang, Mark Levasseur & Keith T. Jones
doi:10.1038/ncb1406
Abstract - | Full Text - APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division | PDF (184 KB) - APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division | Supplementary information


