Sharing science - p425

doi:10.1038/ncb0506-425

Full Text - Sharing science | PDF (106 KB) - Sharing science

The ABCs of centromeres - pp427 - 429

Barbara Mellone, Sylvia Erhardt & Gary H. Karpen

doi:10.1038/ncb0506-427

Accurate segregation of genetic information during cell division relies on a multiprotein complex called the kinetochore, whose formation requires specialized centromeric chromatin. Two papers in this issue of Nature Cell Biology identify a multitude of new vertebrate kinetochore proteins that provide insight into the link between centromeric chromatin and the kinetochore, and suggest a functional relationship between centromeres and nucleoli during interphase.

Full Text - The ABCs of centromeres | PDF (217 KB) - The ABCs of centromeres

Protein expression: one by one - p429

Myrto Raftopoulou

doi:10.1038/ncb0506-429

Full Text - Protein expression: one by one | PDF (123 KB) - Protein expression: one by one

Pore-ing the right dose - pp430 - 431

Christopher R. Brown & Pamela A. Silver

doi:10.1038/ncb0506-430

Dosage compensation in Drosophila melanogaster is distinguished by the hypertranscription of the male X chromosome. New findings show that this process requires the nuclear pore complex.

Full Text - Pore-ing the right dose | PDF (159 KB) - Pore-ing the right dose

Filling the GAP for dynamin - pp432 - 433

Jenny E. Hinshaw

doi:10.1038/ncb0506-432

Endocytosis in eukaryotic cells involves numerous specialized protein complexes and lipid domains. One particularly intriguing protein is dynamin, a large GTPase that is very different from other GTPases. Now, phospholipase D has been identified as surprising regulator of dynamin's GTPase activity.

Full Text - Filling the GAP for dynamin | PDF (286 KB) - Filling the GAP for dynamin

Separating sisters - p434

Sinéad Hayes

doi:10.1038/ncb0506-434

Full Text - Separating sisters | PDF (117 KB) - Separating sisters

Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5 - pp435 - 445

Hassan Mziaut, Mirko Trajkovski, Stephan Kersting, Armin Ehninger, Anke Altkrüger, Régis P. Lemaitre, Darja Schmidt, Hans-Detlev Saeger, Myung-Shik Lee, David N. Drechsel, Stefan Müller & Michele Solimena

doi:10.1038/ncb1395

Abstract - | Full Text - Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5 | PDF (1,031 KB) - Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5 | Supplementary information

The CENP-H–I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres - pp446 - 457

Masahiro Okada, Iain M. Cheeseman, Tetsuya Hori, Katsuya Okawa, Ian X. McLeod, John R. Yates, III, Arshad Desai & Tatsuo Fukagawa

doi:10.1038/ncb1396

Abstract - | Full Text - The CENP-H–I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres | PDF (5,728 KB) - The CENP-H–I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres | Supplementary information

See also: News and Views by Mellone et al.

The human CENP-A centromeric nucleosome-associated complex - pp458 - 469

Daniel R. Foltz, Lars E. T. Jansen, Ben E. Black, Aaron O. Bailey, John R. Yates, III & Don W. Cleveland

doi:10.1038/ncb1397

Abstract - | Full Text - The human CENP-A centromeric nucleosome-associated complex | PDF (2,654 KB) - The human CENP-A centromeric nucleosome-associated complex | Supplementary information

See also: News and Views by Mellone et al.

Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro - pp470 - 476

Megan T. Valentine, Polly M. Fordyce, Troy C. Krzysiak, Susan P. Gilbert & Steven M. Block

doi:10.1038/ncb1394

First Paragraph - | Full Text - Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro | PDF (764 KB) - Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro | Supplementary information

The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis - pp477 - 484

Chang S. Lee, Il S. Kim, Jong B. Park, Mi N. Lee, Hye Y. Lee, Pann-Ghill Suh & Sung H. Ryu

doi:10.1038/ncb1401

First Paragraph - | Full Text - The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis | PDF (1,967 KB) - The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis | Supplementary information

See also: News and Views by Hinshaw

Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling - pp485 - 491

Katsuhiko Asanuma, Etsuko Yanagida-Asanuma, Christian Faul, Yasuhiko Tomino, Kwanghee Kim & Peter Mundel

doi:10.1038/ncb1400

First Paragraph - | Full Text - Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling | PDF (905 KB) - Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling | Supplementary information

Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos - pp492 - 500

Rosana Muñoz, Mauricio Moreno, Carlos Oliva, Claudio Orbenes & Juan Larraín

doi:10.1038/ncb1399

First Paragraph - | Full Text - Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos | PDF (1,663 KB) - Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos | Supplementary information

The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt–-catenin signalling through Dishevelled - pp501 - 508

Yosuke Funato, Tatsuo Michiue, Makoto Asashima & Hiroaki Miki

doi:10.1038/ncb1405

First Paragraph - | Full Text - The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt–-catenin signalling through Dishevelled | PDF (1,412 KB) - The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt–-catenin signalling through Dishevelled | Supplementary information

A ubiquitin-interacting motif protects polyubiquitinated Met4 from degradation by the 26S proteasome - pp509 - 515

Karin Flick, Shahri Raasi, Hongwei Zhang, James L. Yen & Peter Kaiser

doi:10.1038/ncb1402

First Paragraph - | Full Text - A ubiquitin-interacting motif protects polyubiquitinated Met4 from degradation by the 26S proteasome | PDF (3,419 KB) - A ubiquitin-interacting motif protects polyubiquitinated Met4 from degradation by the 26S proteasome | Supplementary information

APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function - pp516 - 523

Xuming Mao, Chintan K. Kikani, Ramon A. Riojas, Paul Langlais, Lixin Wang, Fresnida J. Ramos, Qichen Fang, Christine Y. Christ-Roberts, Jenny Y. Hong, Ryang-Yeo Kim, Feng Liu & Lily Q. Dong

doi:10.1038/ncb1404

First Paragraph - | Full Text - APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function | PDF (7,027 KB) - APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function | Supplementary information

Loss of the VHR dual-specific phosphatase causescell-cycle arrest and senescence - pp524 - 531

Souad Rahmouni, Fabio Cerignoli, Andres Alonso, Toshiya Tsutji, Rachel Henkens, Changjun Zhu, Christine Louis-dit-Sully, Michel Moutschen, Wei Jiang & Tomas Mustelin

doi:10.1038/ncb1398

First Paragraph - | Full Text - Loss of the VHR dual-specific phosphatase causescell-cycle arrest and senescence | PDF (8,672 KB) - Loss of the VHR dual-specific phosphatase causescell-cycle arrest and senescence | Supplementary information

Chromatin signatures of pluripotent cell lines - pp532 - 538

Véronique Azuara, Pascale Perry, Stephan Sauer, Mikhail Spivakov, Helle F. Jørgensen, Rosalind M. John, Mina Gouti, Miguel Casanova, Gary Warnes, Matthias Merkenschlager & Amanda G. Fisher

doi:10.1038/ncb1403

First Paragraph - | Full Text - Chromatin signatures of pluripotent cell lines | PDF (969 KB) - Chromatin signatures of pluripotent cell lines | Supplementary information

APC^cdh1 activity in mouse oocytes prevents entry into the first meiotic division - pp539 - 540

Alexandra Reis, Heng-Yu Chang, Mark Levasseur & Keith T. Jones

doi:10.1038/ncb1406

Abstract - | Full Text - APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division | PDF (184 KB) - APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division | Supplementary information