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Brief Communication
Nature Cell Biology 8, 539–540 (1 May 2006) | doi:10.1038/ncb1406
APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division
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Abstract
Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle.
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