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Letter
Nature Cell Biology 8, 516–523 (1 May 2006) | doi:10.1038/ncb1404
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function
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Abstract
Adiponectin, also known as Acrp30, is an adipose tissue-derived hormone with anti-atherogenic, anti-diabetic and insulin sensitizing properties. Two seven-transmembrane domain-containing proteins, AdipoR1 and AdipoR2, have recently been identified as adiponectin receptors, yet signalling events downstream of these receptors remain poorly defined.
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