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Letter

Nature Cell Biology 8, 509–515 (1 May 2006) | doi:10.1038/ncb1402

A ubiquitin-interacting motif protects polyubiquitinated Met4 from degradation by the 26S proteasome

Karin Flick , Shahri Raasi , Hongwei Zhang , James L. Yen & Peter Kaiser

Covalent attachment of ubiquitin to proteins regulates a host of cellular events by proteolysis dependent and independent mechanisms. A variety of protein domains that bind non-covalently to ubiquitin have been described and functionally linked to diverse cellular processes.