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Letter
Nature Cell Biology 8, 485–491 (1 May 2006) | doi:10.1038/ncb1400
Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling
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Abstract
The Rho family of small GTPases (RhoA, Rac1 and Cdc42) controls signal-transduction pathways that influence many aspects of cell behaviour, including cytoskeletal dynamics. At the leading edge, Rac1 and Cdc42 promote cell motility through the formation of lamellipodia and filopodia, respectively.
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