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Nature Cell Biology 8, 430–431 (1 May 2006) | doi:10.1038/ncb0506-430
Pore-ing the right dose
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Abstract
Organisms with heteromorphic sex chromosomes must ensure that gene expression is equalized between the sexes — a process known as dosage compensation. Decades of research have revealed three different mechanisms by which this is achieved: the hypertranscription of X-linked genes in males (for example, in Drosophila melanogaster); the hypotranscription of X-linked genes in hermaphrodites (for example, in Caenorhabditis elegans), and the shutdown of one of the two X chromosomes in female somatic cells (for example, in mammals).
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