Brief Communication abstract
Nature Cell Biology 8, 539 - 540 (2006)
Published online: 1 May 2006 | doi:10.1038/ncb1406
APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division
Alexandra Reis1,2, Heng-Yu Chang1,2, Mark Levasseur1 & Keith T. Jones1
Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.
- Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle-upon-Tyne, Newcastle, NE2 4HH, UK.
- These authors contributed equally to this work.
Correspondence to: Keith T. Jones1 e-mail: k.t.jones@newcastle.ac.uk
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