Nature Cell Biology 8, 427 - 429 (2006)
doi:10.1038/ncb0506-427
The ABCs of centromeresBarbara Mellone, Sylvia Erhardt
& Gary H. Karpen
Barbara Mellone, Sylvia Erhardt and Gary H. Karpen are in the Department of Genome Biology, Lawrence Berkeley National Lab, and Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA 94720, USA. karpen@fruitfly.org
Accurate segregation of genetic information during cell division relies on a multiprotein complex called the kinetochore, whose formation requires specialized centromeric chromatin. Two papers in this issue of Nature Cell Biology identify a multitude of new vertebrate kinetochore proteins that provide insight into the link between centromeric chromatin and the kinetochore, and suggest a functional relationship between centromeres and nucleoli during interphase.
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