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Letter
Nature Cell Biology 8, 398–406 (1 April 2006) | doi:10.1038/ncb1384
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-|[kappa]|B activation
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Abstract
The transcription factor NF-κB is sequestered in the cytoplasm in a complex with IκB. Almost all NF-κB activation pathways converge on IκB kinase (IKK), which phosphorylates IκB resulting in Lys 48-linked polyubiquitination of IκB and its degradation.
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