1. Hans R. Schöler and Guangming Wu are in the Max Planck Institute for Molecular Biomedicine, Mendelstrasse 7, 48149, Münster, Germany. e-mail: schoeler@mpi-muenster.mpg.de

Abstract

In mammals, the germ-cell lineage separates from the somatic lineages around the time of gastrulation. Primordial germ cells migrate to the developing gonads and become the source of future gametes. Surprisingly, skin stem cells also have the intrinsic ability to develop into oocytes.

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