News and Views
Nature Cell Biology 8, 305 - 307 (2006)
doi:10.1038/ncb0406-305
Chordin cleavage is sizzling
David Kimelman1 & Daniel P. Szeto1
- The authors are in the Department of Biochemistry, Box 357350, University of Washington, Seattle, WA 98195–7350, USA. e-mail: kimelman@u.washington.edu
Abstract
Bone Morphogenetic Protein (Bmp) signalling has a critical function in patterning vertebrate and invertebrate embryos. A key regulator of Bmp signalling is Chordin, which binds Bmps and prevents them from interacting with their receptors. Two new papers identify the Frizzled-related protein Sizzled as an unexpected regulator of Chordin stability.
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