1. Helle D. Ulrich is in the Cancer Research UK Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, UK. e-mail: helle.ulrich@cancer.org.uk

Abstract

Monoubiquitination of the processivity clamp, PCNA, facilitates the replicative bypass of DNA lesions by recruiting damage-tolerant polymerases. In undamaged cells, deubiquitination of PCNA by the deubiquitinating enzyme USP1 reveals a possible safeguard mechanism against the mutagenic effect of these polymerases. Intriguingly, USP1 itself seems to be downregulated by a damage-induced autocatalytic cleavage event.

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