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Nature Cell Biology 8, 209–211 (1 March 2006) | doi:10.1038/ncb0306-209
How APC/C orders destruction
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Abstract
The APC/C coordinates cell-cycle progression through mitosis, meiosis and the G1 phase of the cell cycle. In association with its co-activator proteins — Cdc20 or Cdh1 — APC/C polyubiquitinates regulatory proteins such as securin, cyclin A and geminin, whose subsequent destruction by the 26S proteasome is important for cell-cycle progression (reviewed in ref.
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