1. Jeremy M. Crook, N. Ray Dunn and Alan Colman are in ES Cell International Pte Ltd, 11 Biopolis Way, #05-06 Helios, Singapore 138667. e-mail: acolman@escellinternational.com

Abstract

Embryonic stem (ES) cells deficient in Mbd3, a component of the nucleosome remodelling complex (NuRD), exhibit LIF-independent self-renewal and a restricted potential to differentiate. As such, it is likely that NuRD is required for ES cell pluripotency, and represents a potential link between maintaining the undifferentiated state and the capacity to differentiate.

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