Bettina A. Buschhorn and Jan-Michael Peters are in the Research Institute of Molecular Pathology (IMP), 1030 Vienna, Austria peters@imp.univie.ac.at
The anaphase-promoting complex/cyclosome (APC/C) is a ubiquitin ligase that controls cell-cycle progression by targeting proteins for destruction by the 26S proteasome. The APC/C is active throughout late mitosis and G1 phase but APC/C substrates are degraded in a specific order. A recent study provides insights into how ordered turnover of substrates is achieved.
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