Céline Morey and Wendy Bickmore are in the MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK. Celine.Morey@hgu.mrc.ac.uk
At the onset of mammalian X-chromosome inactivation, the X chromosomes are counted and then a choice is made about which one to inactivate. New findings provide evidence that a transient physical association between X chromosomes in the nucleus might be involved in this process.
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