Table of contents
Editorial
Beautification and fraud - pp101 - 102
doi:10.1038/ncb0206-101
Full Text - Beautification and fraud | PDF (263 KB) - Beautification and fraud
News and Views
The transcellular railway: insights into leukocyte diapedesis - pp105 - 107
Elisabetta Dejana
doi:10.1038/ncb0206-105
Leukocyte recruitment from blood to areas of infection is a key step in both innate and adaptive immunological responses. The predominant model has been that leukocytes transmigrate through the junctions between adjacent endothelial cells. However, leukocytes can also migrate through the endothelial cells, and new insights suggest that both caveolae and intermediate filaments are important for this.
Full Text - The transcellular railway: insights into leukocyte diapedesis | PDF (208 KB) - The transcellular railway: insights into leukocyte diapedesis
See also: Article by Millán et al. | Letter by Nieminen et al.
V-ATPase: a potential pH sensor - pp107 - 109
Chiara Recchi & Philippe Chavrier
doi:10.1038/ncb0206-107
An interaction between V-ATPase, a multi-subunit complex responsible for endosome acidification, and ARNO, the GDP/GTP exchange factor for ARF1 and ARF6, indicates that V-ATPase is the long-sought pH-sensor that regulates trafficking in the endocytic pathway.
Full Text - V-ATPase: a potential pH sensor | PDF (365 KB) - V-ATPase: a potential pH sensor
See also: Article by Hurtado-Lorenzo et al.
INCENP at the kinase crossroads - pp110 - 111
Mar Carmena & William C. Earnshaw
doi:10.1038/ncb0206-110
INCENP — the targeting and activating subunit of Aurora B kinase— has several key mitotic functions. Now, INCENP emerges as a nodal point of the network of kinases that regulate mitotic events. Phosphorylation of INCENP by CDK1 is required for the kinetochore localization of Plk1 kinase, and this in turn is necessary for a timely metaphase–anaphase transition.
Full Text - INCENP at the kinase crossroads | PDF (267 KB) - INCENP at the kinase crossroads
See also: Letter by Goto et al.
microRNA signals cell fate - p112
Myrto Raftopoulou
doi:10.1038/ncb0206-112
Full Text - microRNA signals cell fate | PDF (175 KB) - microRNA signals cell fate
Articles
Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains - pp113 - 123
Jaime Millán, Lindsay Hewlett, Matthew Glyn, Derek Toomre, Peter Clark & Anne J. Ridley
doi:10.1038/ncb1356
Abstract - | Full Text - Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains | PDF (9,866 KB) - Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains | Supplementary information
See also: News and Views by Dejana
V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway - pp124 - 136
Andrés Hurtado-Lorenzo, Mhairi Skinner, Jaafar El Annan, Masamitsu Futai, Ge-Hong Sun-Wada, Sylvain Bourgoin, James Casanova, Alan Wildeman, Shaliha Bechoua, Dennis A. Ausiello, Dennis Brown & Vladimir Marshansky
doi:10.1038/ncb1348
Abstract - | Full Text - V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway | PDF (1,772 KB) - V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway | Supplementary information
See also: News and Views by Recchi & Chavrier
GCP-WD is a 
-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation - pp137 - 147
Jens Lüders, Urvashi K. Patel & Tim Stearns
doi:10.1038/ncb1349
Abstract - | Full Text - GCP-WD is a 
-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation | PDF (2,949 KB) - GCP-WD is a -tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation | Supplementary information
Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication - pp148 - 155
Wenyi Feng, David Collingwood, Max E. Boeck, Lindsay A. Fox, Gina M. Alvino, Walton L. Fangman, Mosur K. Raghuraman & Bonita J. Brewer
doi:10.1038/ncb1358
Abstract - | Full Text - Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication | PDF (4,229 KB) - Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication | Supplementary information
Letters
Vimentin function in lymphocyte adhesion and transcellular migration - pp156 - 162
Mikko Nieminen, Tiina Henttinen, Marika Merinen, Fumiko Marttila–Ichihara, John E. Eriksson & Sirpa Jalkanen
doi:10.1038/ncb1355
First Paragraph - | Full Text - Vimentin function in lymphocyte adhesion and transcellular migration | PDF (1,025 KB) - Vimentin function in lymphocyte adhesion and transcellular migration | Supplementary information
See also: News and Views by Dejana
Regulation of ubiquitin-binding proteins by monoubiquitination - pp163 - 169
Daniela Hoeller, Nicola Crosetto, Blagoy Blagoev, Camilla Raiborg, Ritva Tikkanen, Sebastian Wagner, Katarzyna Kowanetz, Rainer Breitling, Matthias Mann, Harald Stenmark & Ivan Dikic
doi:10.1038/ncb1354
First Paragraph - | Full Text - Regulation of ubiquitin-binding proteins by monoubiquitination | PDF (2,856 KB) - Regulation of ubiquitin-binding proteins by monoubiquitination | Supplementary information
The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1 - pp170 - 179
Karuppiah Muthumani, Andrew Y. Choo, Wei-Xing Zong, Muniswamy Madesh, Daniel S. Hwang, Arumugam Premkumar, Khanh P. Thieu, Joann Emmanuel, Sanjeev Kumar, Craig B. Thompson & David B. Weiner
doi:10.1038/ncb1352
First Paragraph - | Full Text - The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1 | PDF (927 KB) - The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1 | Supplementary information
Complex formation of Plk1 and INCENP required for metaphase–anaphase transition - pp180 - 187
Hidemasa Goto, Tohru Kiyono, Yasuko Tomono, Aie Kawajiri, Takeshi Urano, Koichi Furukawa, Erich A. Nigg & Masaki Inagaki
doi:10.1038/ncb1350
First Paragraph - | Full Text - Complex formation of Plk1 and INCENP required for metaphase–anaphase transition | PDF (1,596 KB) - Complex formation of Plk1 and INCENP required for metaphase–anaphase transition | Supplementary information
See also: News and Views by Carmena & Earnshaw
G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis - pp188 - 194
Nirit Feldman, Ariela Gerson, Jia Fang, En Li, Yi Zhang, Yoichi Shinkai, Howard Cedar & Yehudit Bergman
doi:10.1038/ncb1353
First Paragraph - | Full Text - G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis | PDF (1,321 KB) - G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis | Supplementary information
The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation - pp195 - 202
Sundeep Kalantry, Kyle C. Mills, Della Yee, Arie P. Otte, Barbara Panning & Terry Magnuson
doi:10.1038/ncb1351
First Paragraph - | Full Text - The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation | PDF (1,987 KB) - The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation | Supplementary information
