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Letter
Nature Cell Biology 8, 180–187 (1 February 2006) | doi:10.1038/ncb1350
Complex formation of Plk1 and INCENP required for metaphase|[ndash]|anaphase transition
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Abstract
Mitotic chromosomal dynamics is regulated by the coordinated activities of many mitotic kinases, such as cyclin-dependent kinase 1 (Cdk1), Aurora-B or Polo-like kinase 1 (Plk1), but the mechanisms of their coordination remain unknown. Here, we report that Cdk1 phosphorylates Thr 59 and Thr 388 on inner centromere protein (INCENP), which regulates the localization and kinase activity of Aurora-B from prophase to metaphase.
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