1. Mar Carmena and William C. Earnshaw are at the Wellcome Trust Centre for Cell Biology, Institute for Cell and Molecular Biology, Kings Buildings, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK. e-mail: mar.carmena@ed.ac.uk or e-mail: bill.earnshaw@ed.ac.uk

Abstract

INCENP — the targeting and activating subunit of Aurora B kinase— has several key mitotic functions. Now, INCENP emerges as a nodal point of the network of kinases that regulate mitotic events. Phosphorylation of INCENP by CDK1 is required for the kinetochore localization of Plk1 kinase, and this in turn is necessary for a timely metaphase–anaphase transition.

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