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Nature Cell Biology 8, 107 - 109 (2006)
doi:10.1038/ncb0206-107
V-ATPase: a potential pH sensor
Chiara Recchi1 & Philippe Chavrier1
- Chiara Recchi and Philippe Chavrier are in the Membrane and Cytoskeleton Dynamics Group, UMR144 CNRS/Institut Curie, Paris, France. e-mail: philippe.chavrier@curie.fr
Abstract
An interaction between V-ATPase, a multi-subunit complex responsible for endosome acidification, and ARNO, the GDP/GTP exchange factor for ARF1 and ARF6, indicates that V-ATPase is the long-sought pH-sensor that regulates trafficking in the endocytic pathway.
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