The transcellular railway: insights into leukocyte diapedesis
Elisabetta Dejana
Elisabetta Dejana is in the Department of Biomolecular Sciences and Biotechnology, Faculty of Sciences, University of Milan and FIRC Institute of Molecular Oncology, Milan Italy. elisabetta.dejana@ifom-ieo-campus.it
Leukocyte recruitment from blood to areas of infection is a key step in both innate and adaptive immunological responses. The predominant model has been that leukocytes transmigrate through the junctions between adjacent endothelial cells. However, leukocytes can also migrate through the endothelial cells, and new insights suggest that both caveolae and intermediate filaments are important for this.
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