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Letter
Nature Cell Biology 8, 1415–1423 (1 December 2006) | doi:10.1038/ncb1510
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination
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Abstract
The developmental protein Numb is a major determinant of binary cell fates. It is also required for the differentiation of cerebellar granule cell progenitors (GCPs) at a stage of development responsive to the morphogenic glycoprotein Hedehog.
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