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Letter
Nature Cell Biology 8, 1398–1406 (1 December 2006) | doi:10.1038/ncb1508
A Wnt|[ndash]|Axin2|[ndash]|GSK3|[beta]| cascade regulates Snail1 activity in breast cancer cells
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Abstract
Accumulating evidence indicates that hyperactive Wnt signalling occurs in association with the development and progression of human breast cancer. As a consequence of engaging the canonical Wnt pathway, a β-catenin–T-cell factor (TCF) transcriptional complex is generated, which has been postulated to trigger the epithelial–mesenchymal transition (EMT) that characterizes the tissue-invasive phenotype.
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