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Letter

Nature Cell Biology 8, 1383–1388 (1 December 2006) | doi:10.1038/ncb1505

Exo70 interacts with the Arp2/3 complex and regulates cell migration

Xiaofeng Zuo , Jian Zhang , Ying Zhang , Shu-Chan Hsu , Daoguo Zhou & Wei Guo

The exocyst is a multiprotein complex essential for tethering secretory vesicles to specific domains of the plasma membrane for exocytosis. Here, we report that the exocyst component Exo70 interacts with the Arp2/3 complex, a key regulator of actin polymerization.