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Nature Cell Biology 8, 1325 (1 December 2006) | doi:10.1038/ncb1206-1325
Shaped to split
Abstract
During development, many organs with branched tubule-based structures, including the mammary glands, initially grow in straight lines and subsequently undergo reiterative splitting of the growth activity of the ducts in two directions — a process known as branching morphogenesis. Branching morphogenesis requires tight temporal and spatial integration of a multitude of signals, but analysis of individual factors involved in this process has been difficult.
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