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Nature Cell Biology 8, 1323 - 1325 (2006)
doi:10.1038/ncb1206-1323
Voltage sparks a GPCR
Peter Stanfield1
- Peter Stanfield is in the Molecular Physioloy Group, Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK. e-mail: p.r.stanfield@warwick.co.uk
Abstract
The response of some G-protein coupled receptors (GPRCs) is affected by the voltage across the membrane in which they sit. A study now shows that gating currents, similar to those of ion channels, are associated with this alteration in GPRC activity. The currents depend on structural elements of the receptor that functionally couple to G proteins.
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