Nature Cell Biology
- 8, 1319 - 1321 (2006)
doi:10.1038/ncb1206-1319
eIF4A goes beyond translationMarkus Affolter & George Pyrowolakis
Markus Affolter is in the Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland. George Pyrowolakis is in the Institute of Biology I, University of Freiburg, Hauptstrasse 1, 79104 Freiburg, Germany. markus.affolter@unibas.ch
A new study has revealed an unexpected role for eukaryotic translation initiation factor 4A (eIF4A) in suppressing Decapentaplegic (Dpp) signalling. On activation of Dpp signalling, eIF4A promotes degradation of the downstream signalling components Mad and Medea in a translation-independent manner.
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