1. Heidi L. Galonek and J. Marie Hardwick are in the Department of Molecular Microbiology & Immunology, Johns Hopkins University School of Public Health, Baltimore, MD 21205, USA. e-mail: hardwick@jhu.edu

Abstract

The BCL-2 oncogene promotes cancer progression by prohibiting cell death. BCL-2-related regulators were once thought to constitute a simple, two-class system of anti-death and pro-death factors. New data delineate a multistep hierarchy of BCL-2-family protein interactions that are driven by signal-dependent pathways.

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