Nature Cell Biology
- 8, 1313 - 1316 (2006)
doi:10.1038/ncb1206-1313
DNA replication timing: random thoughts about origin firingNicholas Rhind
Nicholas Rhind is in the Biochemistry and Molecular Pharmacology Department, University of Massachusetts Medical School, 364 Plantation Street, LRB904, Worcester, MA 01605, USA. nick.rhind@umassmed.edu
Regions of metazoan genomes replicate at defined times within S phase. This observation suggests that replication origins fire with a defined timing pattern that remains the same from cycle to cycle. However, an alterative model based on the stochastic firing of origins may also explain replication timing. This model assumes varying origin efficiency instead of a strict origin-timing programme. Here, we discuss the evidence for both models.
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