1. Kaisa Haglund and Harald Stenmark are in the Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital and The University of Oslo, Montebello, 0310 Oslo, Norway. e-mail: stenmark@ulrik.uio.no

Abstract

Ubiquitin receptors that bind ubiquitinated proteins through ubiquitin-binding domains have key roles in various cellular processes. These receptors are often themselves monoubiquitinated, referred to as coupled monoubiquitination. Now, coupled monoubiquitination has been shown to involve monoubiquitination of a ubiquitin ligase and its subsequent interaction with a ubiquitin receptor.

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