Nature Cell Biology
- 8, 1218 - 1219 (2006)
doi:10.1038/ncb1106-1218
Working out coupled monoubiquitinationKaisa Haglund & Harald Stenmark
Kaisa Haglund and Harald Stenmark are in the Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital and The University of Oslo, Montebello, 0310 Oslo, Norway. stenmark@ulrik.uio.no
Ubiquitin receptors that bind ubiquitinated proteins through ubiquitin-binding domains have key roles in various cellular processes. These receptors are often themselves monoubiquitinated, referred to as coupled monoubiquitination. Now, coupled monoubiquitination has been shown to involve monoubiquitination of a ubiquitin ligase and its subsequent interaction with a ubiquitin receptor.
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