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Nature Cell Biology - 8, 1215 - 1217 (2006)
doi:10.1038/ncb1106-1215

Ahead of the curve: mitochondrial fusion and phospholipase D

Robert E. Jensen & Hiromi Sesaki

Robert E. Jensen and Hiromi Sesaki are in the Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. robjensen@jhmi.edu

A new study has identified a novel phospholipase D (PLD) that is located in the mitochondrial outer membrane and is required for organelle fusion. As PLD-catalysed production of fusogenic lipids is critical for many examples of membrane fusion (such as those mediated by SNAREs), this startling finding raises the possibility that mitochondria use a mechanism common to other cellular fusion events.

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Nature Cell Biology
ISSN: 1465-7392
EISSN: 1476-4679
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