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Nature Cell Biology 8, 1215 - 1217 (2006)
doi:10.1038/ncb1106-1215
Ahead of the curve: mitochondrial fusion and phospholipase D
Robert E. Jensen1 & Hiromi Sesaki1
- Robert E. Jensen and Hiromi Sesaki are in the Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. e-mail: robjensen@jhmi.edu
Abstract
A new study has identified a novel phospholipase D (PLD) that is located in the mitochondrial outer membrane and is required for organelle fusion. As PLD-catalysed production of fusogenic lipids is critical for many examples of membrane fusion (such as those mediated by SNAREs), this startling finding raises the possibility that mitochondria use a mechanism common to other cellular fusion events.
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A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosisNature Cell Biology Letter (01 Nov 2006)
