Nature Cell Biology
- 8, 1213 - 1215 (2006)
doi:10.1038/ncb1106-1213
ROS as a tumour suppressor?Matthew R. Ramsey & Norman E. Sharpless
Mathew R. Ramsey and Norman E. Sharpless are in the Departments of Medicine and Genetics, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, NC 27599-7295, USA. nes@med.unc.edu
Senescence is an important mechanism for suppressing mammalian tumours and it may also contribute to aging. A new study suggests that changes in the metabolism of oxygen radicals are important for establishing senescence and blocking cytokinesis to ensure senescent cells never divide again.
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