A new dawn in the land of the rising sun - p1039

doi:10.1038/ncb1006-1039

Full Text - A new dawn in the land of the rising sun | PDF (106 KB) - A new dawn in the land of the rising sun

Organizing cytoplasmic microtubules: no nucleus, no problem - pp1041 - 1043

Tetsuya Horio & Takashi Toda

doi:10.1038/ncb1006-1041

Correct organization of a polarised microtubule array is vital for eukaryotic cells. Microtubule organizing centers (MTOCs) are generally believed to have an essential role in this process. However, two papers published in this issue have demonstrated that in fission yeast, interphase microtubules can self-organize in anucleate cells lacking any authentic MTOC.

Full Text - Organizing cytoplasmic microtubules: no nucleus, no problem | PDF (218 KB) - Organizing cytoplasmic microtubules: no nucleus, no problem

HAUSP hunting the FOX(O) - pp1043 - 1045

Tony T. Huang & Alan D. D'Andrea

doi:10.1038/ncb1006-1043

The forkhead box O (FOXO) family of transcription factors regulate cell stress, cell cycle and cell death pathways. Their activities can be modulated by multiple posttranslational modifications, including phosphorylation and acetylation. A recent study adds a new twist to FOXO regulation, showing that coupled ubiquitination and deubiquitination of FOXO may be important for cellular responses to oxidative stress.

Full Text - HAUSP hunting the FOX(O) | PDF (172 KB) - HAUSP hunting the FOX(O)

Atg5: more than an autophagy factor - pp1045 - 1047

Patrice Codogno & Alfred J. Meijer

doi:10.1038/ncb1006-1045

Atg5 has been previously characterized as a protein specifically required for autophagy, a lysosomal catabolic pathway for proteins and organelles. However, it has now been shown that, in addition to its role in the formation of autophagosomes, an Atg5 fragment produced by calpain cleavage has pro-apoptotic properties.

Full Text - Atg5: more than an autophagy factor | PDF (216 KB) - Atg5: more than an autophagy factor

How wandering cells make a perfect eye - p1047

Nathalie Le Bot

doi:10.1038/ncb1006-1047

Full Text - How wandering cells make a perfect eye | PDF (143 KB) - How wandering cells make a perfect eye

Uncovering stemness - pp1048 - 1049

Mélanie Bilodeau & Guy Sauvageau

doi:10.1038/ncb1006-1048

Understanding how self-renewal and pluripotency — two key characteristics of stem cells — are controlled may allow generation of stem cell lines from somatic tissues, thus avoiding the ethically contentious need to derive them from embryos. A step forward in this understanding was recently taken by two teams, who exploited recombinant retroviruses in gain-and-loss of function experiments to characterize candidate transcription factors with the potential to regulate 'stemness'.

Full Text - Uncovering stemness | PDF (143 KB) - Uncovering stemness

Kizuna takes pole position - pp1050 - 1051

Onur Cizmecioglu & Ingrid Hoffmann

doi:10.1038/ncb1006-1050

A functional bipolar spindle is indispensible for the accurate segregation of chromosomes at mitosis. The centrosomal protein and polo-like kinase-1 (Plk1) substrate Kizuna (Kiz), has now been shown to have a novel function in maintaining spindle-pole integrity and spindle bipolarity.

Full Text - Kizuna takes pole position | PDF (142 KB) - Kizuna takes pole position

Adherens junctions: which way is up? - p1052

Sinéad Hayes

doi:10.1038/ncb1006-1052

Full Text - Adherens junctions: which way is up? | PDF (193 KB) - Adherens junctions: which way is up?

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway - pp1053 - 1063

Christophe Denoyelle, George Abou-Rjaily, Vladimir Bezrookove, Monique Verhaegen, Timothy M. Johnson, Douglas R. Fullen, Jenny N. Pointer, Stephen B. Gruber, Lyndon D. Su, Mikhail A. Nikiforov, Randal J. Kaufman, Boris C. Bastian & Maria S. Soengas

doi:10.1038/ncb1471

Abstract - Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway | Full Text - Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway | PDF (2,346 KB) - Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway | Supplementary information

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP - pp1064 - 1073

Armando van der Horst, Alida M.M. de Vries-Smits, Arjan B. Brenkman, Miranda H. van Triest, Niels van den Broek, Frédéric Colland, Madelon M. Maurice & Boudewijn M.T. Burgering

doi:10.1038/ncb1469

Abstract - FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP | Full Text - FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP | PDF (4,966 KB) - FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP | Supplementary information

See also: News and Views by Huang & D'Andrea

Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability - pp1074 - 1083

Won Ho Yang, Ji Eun Kim, Hyung Wook Nam, Jung Won Ju, Hoe Suk Kim, Yu Sam Kim & Jin Won Cho

doi:10.1038/ncb1470

Abstract - Modification of p53 with : O: -linked : N: -acetylglucosamine regulates p53 activity and stability | Full Text - Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability | PDF (941 KB) - Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability | Supplementary information

Meiotic regulation of the CDK activator RINGO/Speedy by ubiquitin-proteasome-mediated processing and degradation - pp1084 - 1094

Gustavo J. Gutierrez, Andrea Vögtlin, Ana Castro, Ingvar Ferby, Giorgia Salvagiotto, Ze'ev Ronai, Thierry Lorca & Angel R. Nebreda

doi:10.1038/ncb1472

Abstract - Meiotic regulation of the CDK activator RINGO/Speedy by ubiquitin-proteasome-mediated processing and degradation | Full Text - Meiotic regulation of the CDK activator RINGO/Speedy by ubiquitin-proteasome-mediated processing and degradation | PDF (1,476 KB) - Meiotic regulation of the CDK activator RINGO/Speedy by ubiquitin-proteasome-mediated processing and degradation | Supplementary information

The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity - pp1095 - 1101

Naoki Oshimori, Miho Ohsugi & Tadashi Yamamoto

doi:10.1038/ncb1474

Abstract - The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity | Full Text - The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity | PDF (5,058 KB) - The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity | Supplementary information

See also: News and Views by Cizmecioglu & Hoffmann

Self-organization of interphase microtubule arrays in fission yeast - pp1102 - 1107

Rafael E. Carazo-Salas & Paul Nurse

doi:10.1038/ncb1479

Abstract - Self-organization of interphase microtubule arrays in fission yeast | Full Text - Self-organization of interphase microtubule arrays in fission yeast | PDF (1,040 KB) - Self-organization of interphase microtubule arrays in fission yeast | Supplementary information

See also: News and Views by Horio & Toda

Self-organization of microtubule bundles in anucleate fission yeast cells - pp1108 - 1113

Rafael R. Daga, Kyeng-Gea Lee, Scott Bratman, Silvia Salas-Pino & Fred Chang

doi:10.1038/ncb1480

Abstract - Self-organization of microtubule bundles in anucleate fission yeast cells | Full Text - Self-organization of microtubule bundles in anucleate fission yeast cells | PDF (5,995 KB) - Self-organization of microtubule bundles in anucleate fission yeast cells | Supplementary information

See also: News and Views by Horio & Toda

Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1 - pp1114 - 1123

Jinqiu Zhang, Wai-Leong Tam, Guo Qing Tong, Qiang Wu, Hsiao-Yun Chan, Boon-Seng Soh, Yuefei Lou, Jianchang Yang, Yupo Ma, Li Chai, Huck-Hui Ng, Thomas Lufkin, Paul Robson & Bing Lim

doi:10.1038/ncb1481

Abstract - Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of : Pou5f1 | Full Text - Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1 | PDF (2,687 KB) - Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1 | Supplementary information

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis - pp1124 - 1132

Shida Yousefi, Remo Perozzo, Inès Schmid, Andrew Ziemiecki, Thomas Schaffner, Leonardo Scapozza, Thomas Brunner & Hans-Uwe Simon

doi:10.1038/ncb1482

Abstract - Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis | Full Text - Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis | PDF (1,356 KB) - Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis | Supplementary information

See also: News and Views by Codogno & Meijer

Condensin and Repo-Man–PP1 co-operate in the regulation of chromosome architecture during mitosis - pp1133 - 1142

Paola Vagnarelli, Damien F. Hudson, Susana A. Ribeiro, Laura Trinkle-Mulcahy, Jennifer M. Spence, Fan Lai, Christine J. Farr, Angus I. Lamond & William C. Earnshaw

doi:10.1038/ncb1475

Abstract - Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis | Full Text - Condensin and Repo-Man–PP1 co-operate in the regulation of chromosome architecture during mitosis | PDF (6,967 KB) - Condensin and Repo-Man–PP1 co-operate in the regulation of chromosome architecture during mitosis | Supplementary information

Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo - pp1143 - 1148

Homare M. Kubagawa, Jennifer L. Watts, Chad Corrigan, Johnathan W. Edmonds, Elizabeth Sztul, John Browse & Michael A. Miller

doi:10.1038/ncb1476

Abstract - Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment : in vivo | Full Text - Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo | PDF (2,732 KB) - Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo | Supplementary information

A K⁺-selective cGMP-gated ion channel controls chemosensation of sperm - pp1149 - 1154

Timo Strünker, Ingo Weyand, Wolfgang Bönigk, Qui Van, Astrid Loogen, Joel E. Brown, Nachiket Kashikar, Volker Hagen, Eberhard Krause & U.Benjamin Kaupp

doi:10.1038/ncb1473

Abstract - A K: +: -selective cGMP-gated ion channel controls chemosensation of sperm | Full Text - A K+-selective cGMP-gated ion channel controls chemosensation of sperm | PDF (1,107 KB) - A K+-selective cGMP-gated ion channel controls chemosensation of sperm | Supplementary information

The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions - pp1155 - 1162

Stephen Tam, Ron Geller, Christoph Spiess & Judith Frydman

doi:10.1038/ncb1477

Abstract - The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions | Full Text - The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions | PDF (663 KB) - The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions | Supplementary information

Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state - pp1163 - 1169

Akira Kitamura, Hiroshi Kubota, Chan-Gi Pack, Gen Matsumoto, Shoshiro Hirayama, Yasuo Takahashi, Hiroshi Kimura, Masataka Kinjo, Richard I. Morimoto & Kazuhiro Nagata

doi:10.1038/ncb1478

Abstract - Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state | Full Text - Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state | PDF (3,913 KB) - Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state | Supplementary information

Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFB-dependent transcription - pp1171 - 1177

Fei Gao, Jinke Cheng, Tong Shi & Edward T. H. Yeh

doi:10.1038/ncb1483

Abstract - Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NF[kappa]B-dependent transcription | Full Text - Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFB-dependent transcription | PDF (907 KB) - Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFB-dependent transcription | Supplementary information

Erratum - p1178

doi:10.1038/ncb1006-1178a

Full Text - Erratum | PDF (95 KB) - Erratum

Corrigendum - p1178

doi:10.1038/ncb1006-1178b

Full Text - Corrigendum | PDF (66 KB) - Corrigendum