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Nature Cell Biology 8, 1043–1045 (1 October 2006) | doi:10.1038/ncb1006-1043
HAUSP hunting the FOX(O)
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Abstract
FOXO transcription factors function in evolutionarily conserved pathways to regulate cellular longevity and tumour suppression. Historically, FOXO proteins are the major substrates of the protein kinase Akt in response to cellular stimulation by insulin and growth factors.
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