1. Onur Cizmecioglu and Ingrid Hoffmann are in the Department of Cell Cycle Control and Carcinogenesis, F045, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany. e-mail: ingrid.hoffmann@Dkfz-Heidelberg.de

Abstract

A functional bipolar spindle is indispensible for the accurate segregation of chromosomes at mitosis. The centrosomal protein and polo-like kinase-1 (Plk1) substrate Kizuna (Kiz), has now been shown to have a novel function in maintaining spindle-pole integrity and spindle bipolarity.

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