1. Patrice Codogno is in the INSERM U756, University of Paris-Sud 11, 5, rue Jean-Baptiste Cleément, 92296 Châtenay-Malabry, France.
2. Alfred J. Meijer is in the Department of Medical Biochemistry, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. e-mail: patrice.codogno@cep.u-psud.fr

Abstract

Atg5 has been previously characterized as a protein specifically required for autophagy, a lysosomal catabolic pathway for proteins and organelles. However, it has now been shown that, in addition to its role in the formation of autophagosomes, an Atg5 fragment produced by calpain cleavage has pro-apoptotic properties.

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