1. Tony T. Huang and Alan D. D'Andrea are in the Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. e-mail: alan_dandrea@dfci.harvard.edu

Abstract

The forkhead box O (FOXO) family of transcription factors regulate cell stress, cell cycle and cell death pathways. Their activities can be modulated by multiple posttranslational modifications, including phosphorylation and acetylation. A recent study adds a new twist to FOXO regulation, showing that coupled ubiquitination and deubiquitination of FOXO may be important for cellular responses to oxidative stress.

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