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Nature Cell Biology 8, 11–13 (1 January 2006) | doi:10.1038/ncb0106-11
Cdk5 checks p27kip1 in neuronal migration
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Abstract
During both cell proliferation and migration p27kip1 associates with structurally related, but functionally distinct, molecules to provide key signals to the cell. p27kip1 is a member of the Cip-Kip family of cyclin-dependent kinase (Cdk) inhibitors that binds cyclin–Cdk complexes in the nucleus and inhibits their catalytic activity in response to anti-proliferative stimuli.
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