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Letter

Nature Cell Biology 8, 46–54 (1 January 2006) | doi:10.1038/ncb1342

Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells

Oleg O. Glebov , Nicholas A. Bright & Benjamin J. Nichols

Previous studies provide evidence for an endocytic mechanism in mammalian cells that is distinct from both clathrin-coated pits and caveolae, and is not inhibited by overexpression of GTPase-null dynamin mutants. This mechanism, however, has been defined largely in these negative terms.