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Letter
Nature Cell Biology 8, 78–83 (1 January 2006) | doi:10.1038/ncb1341
The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores
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Abstract
The spindle checkpoint ensures accurate chromosome segregation by delaying cell-cycle progression until all sister kinetochores capture microtubules from opposite poles and come under tension (for reviews, see refs 1, 2). Although the checkpoint is activated by either the lack of kinetochore-microtubule attachments or defects in the tension exerted by microtubule-generated forces, it is not clear whether these signals are linked.
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