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Letter
Nature Cell Biology 8, 72–77 (1 January 2006) | doi:10.1038/ncb1340
In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis
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Abstract
Activation of 'initiator' (or 'apical') caspases-2, -8 or -9 (refs 1–3) is crucial for induction of apoptosis. These caspases function to activate executioner caspapses that, in turn, orchestrate apoptotic cell death.
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