1. Michael Downey and Daniel Durocher are in the Department of Medical Genetics and Microbiology, University of Toronto and are located at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, M5G 1X5, Ontario, Canada. e-mail: durocher@mshri.on.ca

Abstract

DNA is tightly wrapped around histones to form chromatin. How DNA repair molecules interact with this chromatin structure is an emerging question. New findings suggest that chromatin structure impedes the access of DNA repair proteins to sites of DNA damage, thus establishing a mechanism for the function of chromatin remodelling complexes during DNA repair.

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