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Letter
Nature Cell Biology 7, 837–843 (1 August 2005) | doi:10.1038/ncb1283
Prohibitin is required for Ras-induced Raf|[ndash]|MEK|[ndash]|ERK activation and epithelial cell migration
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Abstract
Ras proteins control the signalling pathways that are responsible for normal growth and malignant transformation. Raf protein kinases are direct Ras effector proteins that initiate the mitogen-activated protein kinase (MAPK) cascade, which mediates diverse biological functions such as cell growth, survival and differentiation.
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