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Letter
Nature Cell Biology 7, 823–830 (1 August 2005) | doi:10.1038/ncb1282
Temporal and spatial control of nucleophosmin by the Ran|[ndash]|Crm1 complex in centrosome duplication
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Abstract
Centrosome duplication is tightly controlled during faithful cell division, and unnecessary reduplication can lead to supernumerary centrosomes and multipolar spindles that are associated with most human cancer cells. In addition to nucleocytoplasmic transport, the Ran–Crm1 network is involved in regulating centrosome duplication to ensure the formation of a bipolar spindle.
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