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Nature Cell Biology 7, 773–774 (1 August 2005) | doi:10.1038/ncb0805-773
Substrate specificity: PI(3)K|[gamma]| has it both ways
Abstract
PI(3)Ks are a family of lipid kinases that have been implicated in various cellular processes including motility, resistance to apoptosis, and vesicular transport. Ligand-stimulated endocytosis of β-adrenergic receptor (βAR), a G-protein-coupled receptor that is important in the regulation of cardiac function, has previously been shown to require the PI(3)K isoform PI(3)Kγ.
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